Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall.

Macrovascular Thrombosis Is Driven by Tissue Factor Derived Primarily from the Blood Vessel Wall Short Title: Tissue Factor and Macrovascular Thrombosis

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall

Leukocytes and leukocyte-derived microparticles contain low levels of tissue factor (TF) and incorporate into forming thrombi. Although this circulating pool of TF has been proposed to play a key role in thrombosis, its functional significance relative to that of vascular wall TF is poorly defined. We tested the hypothesis that leukocyte-derived TF contributes to thrombus formation in vivo. Com...

Metalloproteinases, Mechanical Factors and Vascular Remodeling

Chronic increases in arterial blood flow elicit an adaptive response of the arterial wall, leading to vessel enlargement and reduction in wall shear stress to physiological baseline value. Release of nitric oxide from endothelial cells exposed to excessive shear is a fundamental step in the remodeling process, and potentially triggers a cascade of events, including growth factor induction and m...

Tissue factor-bearing microparticles and thrombus formation.

Blood microparticles are vesicular structures with a diameter of 100 to 1000 nm that are present in the blood of normal subjects and in patients with various diseases. These microparticles are derived from cells that circulate in the blood and cells associated with the blood vessel wall. Microparticle membranes retain the protein receptors of their parent cells and may retain RNAs and other cyt...

Systems Analysis of Thrombus Formation.

The systems analysis of thrombosis seeks to quantitatively predict blood function in a given vascular wall and hemodynamic context. Relevant to both venous and arterial thrombosis, a Blood Systems Biology approach should provide metrics for rate and molecular mechanisms of clot growth, thrombotic risk, pharmacological response, and utility of new therapeutic targets. As a rapidly created multic...